NS3623

NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels.


Cat. No.: EX-A5263	Purity: >98%

	Chemical structure of NS3623

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	650	In-stock
200mg	950	In-stock
500mg	1550	In-stock
1g	2250	In-stock

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CAS No.	343630-41-1
Purity	>98%
Formula	C15H10BrF3N6O
Mol Weight	427.179
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 250 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hansen RS, et al. In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41. [2]. Diness JG, et al. Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm. 2009 Jan;6(1):100-6. [3]. Calloe K, et al. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem Pharmacol. 2016 May 15;108:36-46.
CoA	CoA of NS3623

Smiles:	O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NNN=N3


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