NRX2663

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCF β-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM .


Cat. No.: EX-A11412	Purity: >98%

	Chemical structure of NRX2663

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	885	In-stock
250mg	1685	In-stock
500mg	2685	Inquire
1g	3985	Inquire

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CAS No.	2763260-34-8
Purity	>98%
Formula	C20H13F3N2O5
Mol Weight	418.3228
Color	White to light yellow
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.
CoA	CoA of NRX2663

Smiles:	OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)OC3=CC=CC=C3)=O)=C1)=O


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