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Product Information:

Nrf2-IN-3

Nrf2-IN-3 (Compound R16) is a small-molecule NRF2 inhibitor and increases reactive oxygen species (ROS) production. Nrf2-IN-3 selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions, leading to proteasome-dependent NRF2 degradation in cells. Nrf2-IN-3 sensitizes KEAP1-mutated tumor cells to Cisplatin, Gefitinib, and KEAP1 G333C-mutated xenograft to Cisplatin .

Cat. No.: EX-A13881    Purity: >98%
Chemical
Chemical structure of Nrf2-IN-3


For research only, Do not use for Human!

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CAS No.6325-13-9
Purity>98%
FormulaC22H26N4O4S
Mol Weight442.531
ColorWhite to off-white
StateSolid
SolubilityDMSO : 116.67 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, 3 years; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Aboulkassim T, et al. A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants. Cell Rep. 2023 Sep 12;42(9):113104.

CoACoA of Nrf2-IN-3
Smiles:O=C(CCCSCCCC(N/N=C/C1=C(O)C=CC=C1)=O)N/N=C/C2=C(O)C=CC=C2

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