Nrf2 degrader 1

Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively.


Cat. No.: EX-A16351	Purity: >98%

	Chemical structure of Nrf2 degrader 1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	498	in-stock
10mg	850	In-stock
25mg	1580	In-stock
50mg	2380	In-stock

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CAS No.	3025286-00-1
Purity	>98%
Formula	C45H42N6O8S
Mol Weight	826.915
Color	white to yellow
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. John Edwin Munroe, et al. Nrf2 protein degraders. WO2024006742A2.
CoA	CoA of Nrf2 degrader 1

Smiles:	O=C1NC(C(N2C(C(C(NCCOCCOC3=CC(CC(NC4=NC(C5=CC=C(N(C(C6=C(C)C=CC=C6)=O)CC7)C7=C5)=C(C)S4)=O)=CC=C3)=CC=C8)=C8C2=O)=O)CC1)=O


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