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Nrf2 activator-21

Nrf2 activator-21 is a Nrf2 activator with dual antioxidant and neuroprotective properties. Nrf2 activator-21 binds to Keap1 Kelch domain and disrupts Keap1-Nrf2 interactions and activate antioxidant defense mechanisms. Nrf2 activator-21 reduces apoptosis and decreases caspase-3 activity in the hippocampal neurons. Nrf2 activator-21 targets cerebral ischemia/reperfusion injury (CIRI) via Nrf2 pathway activation. Nrf2 activator-21 improves neurological function, alleviates anxiety-like behavior, enhances memory in rats with 2-vessel occlusion (2VO)-induced CIRI. Nrf2 activator-21 can be used for the study of cerebral ischemia/reperfusion injury .

Cat. No.: EX-A15792    Purity: >98%
Chemical
Chemical structure of Nrf2 activator-21


For research only, Do not use for Human!

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CAS No.1912404-14-8
Purity>98%
FormulaC19H14O5
Mol Weight322.3115
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Mohammadnia M, et al. Coumarin-Chalcone derivatives as promising antioxidant agents targeting ischemia/reperfusion injury through Nrf2 pathway activation. Bioorg Chem. 2025 Jul 26;164:108790.

CoACoA of Nrf2 activator-21
Smiles:COC1=CC=C2C(OC(C(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)=O)=C1

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