NRAS-G4-ligand-1

NRAS-G4-ligand-1 is a NRAS-G4 binder with Kd values of 0.25 μM (AlexaFluor 647-labeled) and 0.932 μM (biotinylated), respectively. NRAS-G4-ligand-1 acts as a translation inhibitor, reduces cancer cell viability, and downregulates NRAS protein levels. NRAS-G4-ligand-1 can be used in the research of melanoma and breast cancer .


Cat. No.: EX-A17353	Purity: >98%

	Chemical structure of NRAS-G4-ligand-1

For research only, Do not use for Human!

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CAS No.	1185061-66-8
Purity	>98%
Formula	C25H22N6O3S
Mol Weight	486.546
Color	White to off-white
State	solid powder
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Balaratnam S, et al. Investigating the NRAS 5' UTR as a target for small molecules. Cell chemical biology. 2023 Jun 15;30(6):643-657.e8.
CoA	CoA of NRAS-G4-ligand-1

Smiles:	O=S(C1=CC=C(CCNC2=C3C(C=CC=C3)=NC(C4=NN=C(O4)C5=CC=C(C=C5)C)=N2)C=C1)(N)=O


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