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Product Information:

NLRP3-IN-28

NLRP3-IN-28 (compound N77) is a potent inhibitor of NLRP3. NLRP3-IN-28 inhibits Nigericin-induced pyroptosis with an EC50 of 0.07μM. NLRP3-IN-28 alleviates the inflammatory reaction in vivo.

Cat. No.: EX-A8956    Purity: >98%
Chemical
Chemical structure of NLRP3-IN-28


For research only, Do not use for Human!

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CAS No.2922814-80-8
Purity>98%
FormulaC12H9F3N2O3S
Mol Weight318.272
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhou N, et al. Discovery of a novel pyroptosis inhibitor acting though modulating glutathionylation to suppress NLRP3-related signal pathway. Int Immunopharmacol. 2024 Jan 25;127:111314.

CoACoA of NLRP3-IN-28
Smiles:O=S(C1=NN=C(C2=C(O)C=C(C(F)(F)F)C=C2)C=C1)(C)=O

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