[Nle20] H4 peptide (16-23)

[Nle20] H4 peptide (16−23) is a peptide with strong inhibitory activity against histone methyltransferase SETD8 (Kd=0.14 μM), which inhibits SETD8's methylation of histone H4 by competing with SETD8's substrate binding site. [Nle20] H4 peptide (16−23) can be used as a lead compound for anticancer therapy .


Cat. No.: EX-A16068	Purity: >98%

	Chemical structure of [Nle20] H4 peptide (16-23)

For research only, Do not use for Human!

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CAS No.	2042178-19-6
Purity	>98%
Formula	C47H88N20O9
Mol Weight	1077.3302
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Judge R A, et al. Turning a substrate peptide into a potent inhibitor for the histone methyltransferase SETD8[J]. ACS Medicinal Chemistry Letters, 2016, 7(12): 1102-1106.
CoA	CoA of [Nle20] H4 peptide (16-23)

Smiles:	[C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CC(C)C)=O)C(C)C)=O)CCCC)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@H](CCCCN)N)=O)CCCNC(=N)N)=O


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