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Product Information:

Nivocasan

Nivocasan (GS 9450; LB-84451) is a pan-caspase inhibitor that irreversibly arrests caspase-1 activity and inhibits that of caspase-8. Nivocasan inhibits IL-1β cleavage and blocks osteoclast differentiation. Nivocasan inhibits the protein expression of NFATc1 and CSTK .

Cat. No.: EX-A16225    Purity: >98%
Chemical
Chemical structure of Nivocasan


For research only, Do not use for Human!

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SynonymsGS 9450
Synonyms 2LB-84451
CAS No.908253-63-4
Purity>98%
FormulaC21H22FN3O5
Mol Weight415.4149
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1].Kim HY, et al. Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion. Oxid Med Cell Longev. 2019 Apr 22;2019:3503912.

CoACoA of Nivocasan
Smiles:C(N[C@@H]1[C@](CF)(O)OC(=O)C1)(=O)[C@]2(C(C)C)CC(=NO2)C=3C4=C(C=CN3)C=CC=C4

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