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Product Information:

Nilotinib monohydrochloride monohydrate

Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent against BCR-ABL, and is active against many BCR-ABL mutants.

Cat. No.: EX-A8380A    Purity: >99%
Chemical
Chemical structure of Nilotinib monohydrochloride monohydrate


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10g420in_stock
20g773in_stock
50g1599in_stock
100g2854in_stock


SynonymsAMN107 monohydrochloride monohydrate
CAS No.923288-90-8
Purity>99%
FormulaC28H25ClF3N7O2
Mol Weight583.992
Colorwhite to light yellow
Statesolid powder
SolubilityDMSO : 33.33 mg/mL H2O : 12.9 mg/mL
Shelf Life>1 years if stored properly
Storage4°C, sealed storage, away from moisture
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Weisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.

[2]. Sako H, et al. Antitumor effect of the tyrosine kinase inhibitor Nilotinib on gastrointestinal stromal tumor (GIST) and Imatinib-resistant GIST cells. PLoS One. 2014 Sep 15;9(9):e107613.

[3]. Dervis Hakim G, et al. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol. 2015 Nov 28;21(44):12576-85.

CoACoA of Nilotinib monohydrochloride monohydrate
Smiles:Cl.O=C(NC=1C=C(C=C(C1)C(F)(F)F)N2C=NC(=C2)C)C3=CC=C(C(=C3)NC=4N=CC=C(N4)C5=CN=CC=C5)C.O

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