Nikkomycin Z

Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity.


Cat. No.: EX-A13443	Purity: >98%

	Chemical structure of Nikkomycin Z

For research only, Do not use for Human!

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CAS No.	59456-70-1
Purity	>98%
Formula	C20H25N5O10
Mol Weight	495.44
Color	White to off-white
State	Solid
Solubility	H2O : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. R Kovács, et al. Synergistic Effect of Nikkomycin Z With Caspofungin and Micafungin Against Candida Albicans and Candida Parapsilosis Biofilms. Lett Appl Microbiol. 2019 Oct;69(4):271-278. [2]. Goldberg J, et al. Comparison of nikkomycin Z with amphotericin B and itraconazole for treatment of histoplasmosis in a murine model. Antimicrobial Agents and Chemotherapy, 2000, 44(6): 1624-1629. [3]. Nix DE, et al. Pharmacokinetics of nikkomycin Z after single rising oral doses. Antimicrob Agents Chemother. 2009 Jun;53(6):2517-21.
CoA	CoA of Nikkomycin Z

Smiles:	O[C@H]1[C@@H](O[C@]([C@H](NC([C@H]([C@@H]([C@H](O)C2=CC=C(O)C=N2)C)N)=O)C(O)=O)([C@H]1O)[H])N3C(=O)NC(=O)C=C3


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