Nic-15

Nic-15 (compound 4n) is an anti-constrictive agent used to antagonize the hypovascularity of pancreatic tumors. The hypovascularity allows cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop drug resistance. Nic-15 can regulate the PI3K/Akt/mTOR pathway and alleviate ER stress induced by Gemcitabine. Nic-15 can significantly inhibit the migration and colony formation of MIA PaCa-2 and PANC-1 pancreatic cancer cells. The combination of Nic-15 and Gemcitabine can effectively solve the problem of pancreatic tumor resistance. In an in vivo xenograft model, Nic-15 can significantly enhance the efficacy of Gemcitabine.


Cat. No.: EX-A13205	Purity: >98%

	Chemical structure of Nic-15

For research only, Do not use for Human!

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CAS No.	2896739-91-4
Purity	>98%
Formula	C25H26F2O3
Mol Weight	412.4689
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations
CoA	CoA of Nic-15

Smiles:	C(=O)([C@H]1[C@@H](CC(CCC=C(C)C)=CC1)C2=C(F)C(F)=CC=C2)C3=C(O)C=CC=C3O


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