NHWD-870

NHWD-870 is a potent, orally active and selective BET family bromodomain inhibitor and only binds bromodomains of BRD2, BRD3, BRD4 (IC50=2.7 nM), and BRDT. NHWD-870 has potent tumor suppressive efficacies and suppresses cancer cell-macrophage interaction. NHWD-870 increases tumor apoptosis and inhibits tumor proliferation .


Cat. No.: EX-A17431	Purity: >98%

	Chemical structure of NHWD-870

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	732	Inquire
50mg	1188	In-stock
100mg	2185	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2115742-03-3
Purity	>98%
Formula	C29H29N7O
Mol Weight	491.5869
Color	White to off-white
State	Solid
Solubility	DMSO : 62.5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Yin M, et al. Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction. Nat Commun. 2020;11(1):1833. Published 2020 Apr 14. [2].Nenghui Wang, et al. Abstract 1382: A novel BET family bromodomain inhibitor NHWD-870 represents a promising therapeutic agent for a broad spectrum of cancers. Molecular and Cellular Biology, Genetics.
CoA	CoA of NHWD-870

Smiles:	[C@@H](N1C=2C(C=3C1=CC(=CN3)C4=C(C)N=NN4C)=CC5=C(C2)N(C)N=C5)(C6=CC=CC=C6)C7CCOCC7


		Search