Neurokinin B TFA

Neurokinin B TFA is a tachykinin family peptide that preferentially binds to and activates NK3R over other tachykinin receptors. Neurokinin B TFA preferentially binds to the substance P receptor (SP-N receptor) and mediates acetylcholine release from cholinergic neurons. Neurokinin B TFA regulates the pulsatile release of Kisspeptin and GnRH, stimulates or inhibits the secretion of luteinizing hormone, regulates reproductive function via metabolic signals, and drives the onset of puberty. Neurokinin B TFA exerts vasoactive effects and induces contraction of isolated guinea pig ileum. Neurokinin B TFA can be used in studies related to hypogonadotropic hypogonadism.


Cat. No.: EX-A12119	Purity: >98%

	Chemical structure of Neurokinin B TFA

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	390	In-stock
25mg	780	In-stock
50mg	1230	In-stock
100mg	1980	In-stock
250mg	3990	In-stock
500mg	6350	In-stock

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CAS No.	101536-55-4
Purity	>98%
Formula	C57H80F3N13O16S2
Mol Weight	1324.448
Color	White to off-white
State	Solid
Solubility	DMSO : ? 33.33 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -80°C, 2 years , -20°C, 1 year, Sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47. [2]. Jayasena CN, et al. Effects of neurokinin B administration on reproductive hormone secretion in healthy men and women. The Journal of clinical endocrinology and metabolism. 2014 Jan;99(1):E19-27. [3]. Billings HJ, et al. Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology. 2010 Aug;151(8):3836-46. [4]. Laufer R, et al. Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proceedings of the National Academy of Sciences of the United States of America. 1985 Nov;82(21):7444-8.
CoA	CoA of Neurokinin B TFA

Smiles:	C(C(O)=O)(F)(F)F.[C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)[C@@H](C)C)=O)=O)NC([C@@H](NC([C@H](CC3=CN=CN3)NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCSC)=O)=O)CC(O)=O)=O


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