NEO214

NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol. It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma.


Cat. No.: EX-A8911	Purity: >98%

	Chemical structure of NEO214

For research only, Do not use for Human!

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CAS No.	1361198-80-2
Purity	>98%
Formula	C27H35NO5
Mol Weight	453.5705
Color	Colorless to off-white
State	Oil
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ou M, et al. Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate. Autophagy. 2023 Dec;19(12):3169-3188.
CoA	CoA of NEO214

Smiles:	O=C(N1C(CC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1)=O)OCC4=CC[C@@H](C(C)=C)CC4


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