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Product Information:

NEK7 degrader-3

NEK7 degrader-3 is an orally active and brain-penetrant NEK7 molecular glue degrader with a DC50 of 33.1 nM. NEK7 degrader-3 mediates interaction between NEK7 and E3 ligase cereblon, promoting proteasomal degradation of NEK7 and attenuating NLRP3 inflammasome-mediated inflammatory responses. NEK7 degrader-3 inhibits caspase-1 activity, cytokine release of IL-1β, IL-1α, and IL-18, and pyroptosis-related plasma membrane permeabilization. NEK7 degrader-3 shows antiinflammatory activity in an LPS -induced neuroinflammation mouse model. NEK7 degrader-3 can be used for the research of neuroinflammation .

Cat. No.: EX-A16911    Purity: >98%
Chemical
Chemical structure of NEK7 degrader-3


For research only, Do not use for Human!

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CAS No.3119435-52-5
Purity>98%
FormulaC16H13Cl2N3O4
Mol Weight382.198
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. LIARDO Elisa, et al. TARGETED PROTEIN DEGRADATION. WO2026052637. 2026-3-12

CoACoA of NEK7 degrader-3
Smiles:O=C1C(C2=C(Cl)C=C(OC3(CC3)C4=NN=CO4)C=C2Cl)CCC(N1)=O

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