Nedisertib

Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity .


Cat. No.: EX-A1679	Purity: >98%

	Chemical structure of Nedisertib

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	685	in_stock
500mg	1064	in_stock
1g	1787	in_stock
2g	3145	in_stock
5g	5296	in_stock

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Synonyms	M-3814
CAS No.	1637542-33-6
Purity	>98%
Formula	C24H21ClFN5O3
Mol Weight	481.907
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wu ZX, et al. M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells. Front Oncol. 2020 May 12;10:674. [2]. L. Damstrup, et al. M3814, a DNA-dependent Protein Kinase Inhibitor (DNA-PKi), Potentiates the Effect of Ionizing Radiation (IR) in Xenotransplanted Tumors in Nude Mice. IJROBP. 2016; 94, 940-941. [3]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1. 2014-11-20.
CoA	CoA of Nedisertib

Smiles:	COC1=NN=C(C=C1)[C@@H](O)C1=CC(=C(F)C=C1Cl)C1=C2C=CC(=CC2=NC=N1)N1CCOCC1


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