NB-598

NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


Cat. No.: EX-A1748	Purity: >98%

	Chemical structure of NB-598

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	750	In-stock
500mg	1200	In-stock
1g	2100	In-stock
5g	get quote	In-stock
10g	get quote	In-stock

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CAS No.	131060-14-5
Purity	>98%
Formula	C27H31NOS2
Mol Weight	449.671
Color	off-white to light yellow
State	solid
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. [2]. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. [3]. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.
CoA	CoA of NB-598

Smiles:	CCN(C\C=C\C#CC(C)(C)C)CC1=CC=CC(OCC2=CC(=CS2)C2=CSC=C2)=C1


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