NAV1.7-IN-8

Nav1.7-IN-8 is a potent blockage of NaV1.7 with high selectivity for the inhibition of NaV1.7 over the subtypes hNaV1.1 and hNaV1.5. Nav1.7-IN-8 inhibits CYP2C9 and CYP3A4 with an IC50 of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 displays significant analgesic effects in rodent models of acute and inflammatory pain .


Cat. No.: EX-A9943	Purity: >98%

	Chemical structure of NAV1.7-IN-8

For research only, Do not use for Human!

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CAS No.	1432913-44-4
Purity	>98%
Formula	C21H12ClF2N5O4S2
Mol Weight	535.931
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Focken T, et al. Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models. ACS Med Chem Lett. 2016;7(3):277-282. Published 2016 Jan 19.
CoA	CoA of NAV1.7-IN-8

Smiles:	O=S(=O)(NC1=NC=NS1)C=2C=C(F)C(OC=3C=CC(Cl)=CC3C4=CC=C5ON=C(N)C5=C4)=CC2F


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