Naperiglipron

Naperiglipron (LY3549492) (Example 2) is a Glucagon-like peptide 1 receptor (GLP-1R) agonist with an EC50 of 1.14 nM for hGLP-1R. Naperiglipron significantly decreases the level of blood glucose in GLP-1R knock-in mouse models. Naperiglipron inhibits PDE10A1 enzyme activity (IC50: 7.43 μM) with a weak hERG inhibitory activity. Naperiglipron can be used for type II diabetes mellitus (T2DM) and obesity research .


Cat. No.: EX-A15677	Purity: >98%

	Chemical structure of Naperiglipron

For research only, Do not use for Human!

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Synonyms	LY3549492
CAS No.	2572566-11-9
Purity	>98%
Formula	C33H26F2N4O4
Mol Weight	580.5807
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Coates D A, et al. Glucagon-like peptide 1 receptor agonists. WO2020263695A1. 2020-12-30.
CoA	CoA of Naperiglipron

Smiles:	FC(C=C(C=C1)C#N)=C1COC2=NC(C(C(C)=C3)=CC(F)=C3CC4=NC5=CC=C(C(O)=O)C=C5N4C[C@H]6OCC6)=CC=C2


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