NAMPT inhibitor-linker 2

NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.


Cat. No.: EX-A17531	Purity: >98%

	Chemical structure of NAMPT inhibitor-linker 2

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	483	in_stock
25mg	961	in_stock
50mg	1526	in_stock
100mg	2425	in_stock
250mg	4888	in_stock
500mg	7814	in_stock

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CAS No.	2241014-82-2
Purity	>98%
Formula	C34H33FN6O5
Mol Weight	624.6614
Color	Off-white to light yellow
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.
CoA	CoA of NAMPT inhibitor-linker 2

Smiles:	FC1=CC(NC([C@@H]2[C@H](C2)C3=CN=CC=C3)=O)=CC=C1CNC(C4=CC=C(N5CCN(C(CCN6C(C=CC6=O)=O)=O)CC5)C=C4)=O


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