NA-184

NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) .


Cat. No.: EX-A9814	Purity: >98%

	Chemical structure of NA-184

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	get quote	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2688119-39-1
Purity	>98%
Formula	C27H35ClN4O5
Mol Weight	531.044
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Baudry M, et al. Identification and neuroprotective properties of NA-184, a calpain-2 inhibitor. Pharmacol Res Perspect. 2024 Apr;12(2):e1181.
CoA	CoA of NA-184

Smiles:	ClC1=CC=CC(CNC(C(C(CC)NC([C@H](CC(C)C)NC(NCC2=CC=CC=C2)=O)=O)=O)=O)=C1OC


		Search