Myriocin

Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection.


Cat. No.: EX-A12289	Purity: >98%

	Chemical structure of Myriocin

For research only, Do not use for Human!

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CAS No.	35891-70-4
Purity	>98%
Formula	C21H39NO6
Mol Weight	401.5375
Color	White to off-white
State	solid
Solubility	DMSO : 2 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. He Q, et, al. Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. Mycopathologia. 2004 Apr;157(3):339-47. [2]. Amemiya F, et, al. Targeting lipid metabolism in the treatment of hepatitis C virus infection. J Infect Dis. 2008 Feb 1;197(3):361-70. [3]. Ciesek S, et, al. The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis. 2008 Oct 1;198(7):1091-3.
CoA	CoA of Myriocin

Smiles:	[C@]([C@H]([C@@H](C/C=C/CCCCCCC(CCCCCC)=O)O)O)(C(O)=O)(CO)N


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