MY-1B

MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes.


Cat. No.: EX-A13161	Purity: >98%

	Chemical structure of MY-1B

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2929308-79-0
Purity	>98%
Formula	C22H18BrN3O2
Mol Weight	436.301
Color	White to off-white
State	Solid
Solubility	DMSO : ? 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, stored under nitrogen; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tao Y, et al. Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2. Angew Chem Int Ed Engl. 2023 Dec 18;62(51):e202311924. [2]. Tao Y, et al. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. J Am Chem Soc. 2022 Oct 12;144(40):18688-18699. [3]. Ng BW, et al. Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics. Mol Cell. 2023 May 18;83(10):1544-1546.
CoA	CoA of MY-1B

Smiles:	O=C([C@H]1[C@@H](C2=CC=C(C=C2)Br)CN1C(C=C)=O)NC3=CC=CC4=C3N=CC=C4


		Search