MutantIDH1/NAMPT-IN-1

Mutant IDH1/NAMPT-IN-1 (Compound 23h) is a dual inhibitor of mutant isocitrate dehydrogenase 1 (mutant IDH1) (IC50=14.93 nM) and nicotinamide phosphoribosyltransferase (NAMPT) (IC50=12.56 nM). Mutant IDH1/NAMPT-IN-1 can induce apoptosis. Mutant IDH1/NAMPT-IN-1 crosses the blood-brain barrier effectively.


Cat. No.: EX-A17031	Purity: >98%

	Chemical structure of MutantIDH1/NAMPT-IN-1

For research only, Do not use for Human!

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CAS No.	3040122-14-0
Purity	>98%
Formula	C30H29FN6O4
Mol Weight	556.5875
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wen F, et al. Discovery of Novel Dual Inhibitors Targeting Mutant IDH1 and NAMPT for the Treatment of Glioma with IDH1Mutation. J Med Chem. 2024 Apr 23.
CoA	CoA of MutantIDH1/NAMPT-IN-1

Smiles:	C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)NC(COC3=CC=CN=C3)=O)NC4=NC(N5[C@H](COC5=O)[C@H](C)F)=CC=N4


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