MTX115325

MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine .


Cat. No.: EX-A9281	Purity: >98%

	Chemical structure of MTX115325

For research only, Do not use for Human!

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CAS No.	2750895-97-5
Purity	>98%
Formula	C18H16N6O2
Mol Weight	348.3586
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Fang TZ et al. Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model. Nat Commun. 2023 Nov 13;14(1):7295.
CoA	CoA of MTX115325

Smiles:	C(=O)(N1[C@@]2([C@@]([C@@H](C)N(C#N)C2)(CC1)[H])[H])C=3OC(=CN3)C=4C=C(C#N)N=CC4


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