MTX-531

MTX-531 is a potent and selective inhibitor of EGFR and PI3K, with IC50s of 14.7 nM and 1.1-233 nM (differ in subtype). MTX-531 can also act as a weak agonist of PPARγ, with the EC50 of 3.4 μM in 293H cells .


Cat. No.: EX-A9777	Purity: >98%

	Chemical structure of MTX-531

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	812	in_stock
250mg	1447	in_stock
500mg	2403	in_stock
1g	4143	in_stock

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CAS No.	2791417-66-6
Purity	>98%
Formula	C22H20ClN5O2S
Mol Weight	453.945
Color	off-white to light yellow
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 2-8 ℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Christopher E Whitehead, et al. A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance. Nat Cancer. 2024 Jul 11.
CoA	CoA of MTX-531

Smiles:	ClC1=C(NS(=O)(C)=O)C=C(C2=CC3=C(N=CN=C3N[C@@H](C4=CC=CC=C4)C)C=C2)C=N1


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