MTHFD2-IN-6

MTHFD2-IN-6 is an orally active selective inhibitor of MTHFD2, with a human IC50 of 1.46 μM. MTHFD2-IN-6 binds directly to MTHFD2, selectively inhibits cancer cell proliferation, promotes ROS accumulation in cancer cells, and induces cancer cell cycle arrest and apoptosis. MTHFD2-IN-6 inhibits tumor growth in Mus musculus xenograft models. MTHFD2-IN-6 can be used for lung cancer research.


Cat. No.: EX-A14023	Purity: >98%

	Chemical structure of MTHFD2-IN-6

For research only, Do not use for Human!

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CAS No.	3077252-76-4
Purity	>98%
Formula	C21H21ClO5
Mol Weight	388.841
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hu Y, et al.. Hit to lead optimization of isopentenyl chalcones as novel MTHFD2 inhibitors for cancer treatment: design, synthesis, in-vitro, in-vivo and in-silico studies. European journal of medicinal chemistry. 2025 Aug 05;292:117703.
CoA	CoA of MTHFD2-IN-6

Smiles:	O=C(C1=C(O)C=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(Cl)C(OC)=C2


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