MT-110

MT-110 (BPN-0027490) is a non-muscle myosin NMIIB-selective inhibitor with high brain penetration and favorable safety profile. MT-110 specifically disrupts NMIIB-dependent actin dynamics in dendritic spines, while it exerts no significant adverse effects on cardiac myosin II and cardiac functions (such as cardiac output and heart rate) at tested concentrations. A single administration of MT-110 produces long-lasting (sustained for several weeks) blockade of methamphetamine motivation associated with environmental cues. MT-110 exhibits extremely high specificity, with no interference with cocaine motivation, hippocampus-dependent memory, fear memory, or locomotor and anxiety-like behaviors. MT-110 serves as a valuable tool compound for investigating the mechanisms of methamphetamine use disorder .


Cat. No.: EX-A16623	Purity: >98%

	Chemical structure of MT-110

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	550	In-stock
25mg	985	In-stock
50mg	1485	In-stock
100mg	2285	In-stock
250mg	3285	In-stock
500mg	4685	In-stock

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Synonyms	4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6,7-dimethyl-1-(2-methyl-6-quinolinyl)-, (3aS)-
Synonyms 2	BPN-0027490
CAS No.	2404652-82-8
Purity	>98%
Formula	C23H21N3O2
Mol Weight	371.4317
Color	Light yellow to yellow
State	solid Powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Radnai L, et al. Development of clinically viable non-muscle myosin II small molecule inhibitors. Cell. 2025;188(17):4604-4621.e15.
CoA	CoA of MT-110

Smiles:	CC1=NC2=C(C=C1)C=C(C=C2)N3CCC4(C3=NC5=C(C4=O)C=C(C(=C5)C)C)O


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