MS8790

MS8709 (compound 10), a potential anticancer therapeutic, is a first-in-class G9a/GLP PROTAC degrader. MS8709 is based on G9a/GLP inhibitor UNC0642 and recruits the von Hippel Lindau (VHL) E3 ligase (Red: G9a/GLP inhibitor UNC0642; Blue: VHL ligand; Black: linker).


Cat. No.: EX-A11295	Purity: >98%

	Chemical structure of MS8790

For research only, Do not use for Human!

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CAS No.	3060730-06-2
Purity	>98%
Formula	C64H95F2N11O7S
Mol Weight	1200.57
Color	White to off-white
State	solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Julia Velez, et al. Discovery of the First-in-class G9a/GLP PROTAC Degrader. BioRxiv. Posted February 29, 2024.
CoA	CoA of MS8790

Smiles:	N(C=1C2=C(N=C(N1)N3CCC(F)(F)CC3)C=C(OCCCN4CCCC4)C(OC)=C2)C5CCN(CCCC(NCCCCCCCCCCCC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)[C@](C)(C)C)=O)=O)CC5


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