MRTX-1257

MRTX-1257 is a selective, irreversible, covalent and oral active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.


Cat. No.: EX-A3343	Purity: >98%

	Chemical structure of MRTX-1257

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	585	In-stock
250mg	900	In-stock
1g	1900	In-stock
3g	3900	In-stock
5g	5600	In-stock
10g	8450	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2206736-04-9
Purity	>98%
Formula	C33H39N7O2
Mol Weight	565.7085
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Matthew et al. Structure-Based Drug Discovery of MRTX1257, a Selective, Covalent KRAS G12C Inhibitor with Oral Activity in Animal Models of Cancer.
CoA	CoA of MRTX-1257

Smiles:	N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1


		Search