MRL-494 hydrochloride

MRL-494 hydrochloride, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 hydrochloride can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias.


Cat. No.: EX-A17088	Purity: >98%

	Chemical structure of MRL-494 hydrochloride

For research only, Do not use for Human!

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CAS No.	2699937-04-5
Purity	>98%
Formula	C26H36ClFN16O2
Mol Weight	659.121
Color	White to off-white
State	Solid
Solubility	H2O : 110 mg/mL DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light, stored under nitrogen; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hart EM, A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21748-21757.
CoA	CoA of MRL-494 hydrochloride

Smiles:	FC1=CC=C(C2=NN(CC(N[C@@H]3CC[C@H](NC4=NC(NC(C5CC5)CC(NC(N)=N)=O)=NC(NC(N)=N)=N4)CC3)=O)N=N2)C=C1.[H]Cl


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