MR22

MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells.


Cat. No.: EX-A11589	Purity: >98%

	Chemical structure of MR22

For research only, Do not use for Human!

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CAS No.	3027761-24-3
Purity	>98%
Formula	C18H19F2N5O
Mol Weight	359.3732
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Marcel Rak, et al. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. European Journal of Medicinal Chemistry. Volume 254, 5 June 2023, 115347.
CoA	CoA of MR22

Smiles:	O=C1C(=CC=2C=NC(=NC2N1CCCCN)NC)C3=CC(F)=CC=C3F


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