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Product Information:

MPO-IN-8

MPO-IN-8 is an orally active myeloperoxidase (MPO) inhibitor. MPO-IN-8 can inhibit the generation of hypochlorous acid in neutrophils and the release of extracellular traps (NETosis). In mice with gouty arthritis, MPO-IN-8 can reduce swelling, lower peroxidase activity, and decrease IL-1β levels.

Cat. No.: EX-A13382    Purity: >98%
Chemical
Chemical structure of MPO-IN-8


For research only, Do not use for Human!

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CAS No.62578-87-4
Purity>98%
FormulaC12H9N3O2
Mol Weight227.2188
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Matos IA, et al. Targeting Myeloperoxidase Ameliorates Gouty Arthritis: A Virtual Screening Success Story. J Med Chem. 2024 Jul 25;67(14):12012-12032.

CoACoA of MPO-IN-8
Smiles:O=C1C2=C3C(C(N1N)=O)=CC(N)=CC3=CC=C2

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