Mozenavir

Mozenavir (DMP 450) is an orally active and highly selective inhibitor of HIV-1 protease (Ki=0.3 nM). Mozenavir blocks the cleavage and processing of viral polyproteins, inhibiting the replication and maturation of HIV-1. Mozenavir is promising for research of HIV infection .


Cat. No.: EX-A15958	Purity: >98%

	Chemical structure of Mozenavir

For research only, Do not use for Human!

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Synonyms	DMP-450
CAS No.	174391-92-5
Purity	>98%
Formula	C33H36N4O3
Mol Weight	536.6639
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mamidala E, et al. In silico prediction of mozenavir as a potential drug for SARS-CoV-2 infection via binding multiple drug targets. Saudi J Biol Sci. 2022 Feb;29(2):840-847. [2]. Karpoormath R, et al. Novel PCU cage diol peptides as potential targets against wild-type CSA HIV-1 protease: synthesis, biological screening and molecular modelling studies[J]. Medicinal Chemistry Research, 2013, 22: 3918-3933. [3]. Hodge CN, et al. Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450. Chem Biol. 1996 Apr;3(4):301-14.
CoA	CoA of Mozenavir

Smiles:	C(N1[C@H](CC2=CC=CC=C2)[C@H](O)[C@@H](O)[C@@H](CC3=CC=CC=C3)N(CC4=CC(N)=CC=C4)C1=O)C5=CC(N)=CC=C5


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