Mouse TREM-1 SCHOOL peptide

Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets the interaction between TREM-1 and its signaling partner DAP-12, specifically silencing the TREM-1 signaling pathway, regulate the production of TREM-1-mediated pro-inflammatory cytokines in vivo and in vitro. Mouse TREM-1 SCHOOL peptide has anti-tumor effects. Mouse TREM-1 SCHOOL peptide can reduce the formation of vitreoretinal neovascularization .


Cat. No.: EX-A9282	Purity: >98%

	Chemical structure of Mouse TREM-1 SCHOOL peptide

For research only, Do not use for Human!

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Synonyms	Mouse TREM-1(213–221), GF9
CAS No.	1292755-24-8
Purity	>98%
Formula	C46H78N10O12
Mol Weight	963.1713
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture, 1 year; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sigalov AB. A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock. Int Immunopharmacol. 2014 Jul;21(1):208-19. [2]. Rojas MA, et al. Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy. Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2761-2768.
CoA	CoA of Mouse TREM-1 SCHOOL peptide

Smiles:	[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)[C@@H](C)C)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC(C)C)=O)CC(C)C)=O)CO)=O)CCCCN)=O)CO)=O)CC(C)C


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