MMRi62

MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.


Cat. No.: EX-A14129	Purity: >98%

	Chemical structure of MMRi62

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	525	In-stock
500mg	725	In-stock
1g	1025	In-stock

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CAS No.	352693-80-2
Purity	>98%
Formula	C21H15Cl2N3O
Mol Weight	396.269
Color	White to off-white
State	Solid
Solubility	DMSO : 62.5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li J, et al. Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53. Mol Cancer Ther. 2022 Apr 1;21(4):535-545. [2]. Lama R, et al. Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status. Front Oncol. 2022 Aug 5;12:933446.
CoA	CoA of MMRi62

Smiles:	C1=CC=NC(=C1)NC(C2=C(C(=CC=C2)Cl)Cl)C3=C(C4=C(C=CC=N4)C=C3)O


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