ML390

ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models.


Cat. No.: EX-A5628	Purity: >98%

	Chemical structure of ML390

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	875	In-stock
1g	1275	In-stock
5g	3950	In-stock
10g	6300	In-stock

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CAS No.	2029049-79-2
Purity	>98%
Formula	C21H21F3N2O3
Mol Weight	406.3982
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO ? 27 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs

Reference:	[1]. Sykes DB et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. National Center for Biotechnology Information (US); 2010-2013 Dec 15. [2]. David B Sykes, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016 Sep 22;167(1):171-186.e15. [3]. Timothy A Lewis, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117.
CoA	CoA of ML390


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