ML381 Fumarate

ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies.


Cat. No.: EX-A9415A	Purity: >98%

	Chemical structure of ML381 Fumarate

For research only, Do not use for Human!

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Synonyms	VU0488130 Fumarate
Purity	>98%
Formula	C25H25N3O8
Mol Weight	495.4813
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gentry, Patrick R., et al. “Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity.” Probe Reports from the NIH Molecular Libraries Program, National Center for Biotechnology Information (US), 15 December 2013. [2]. Gentry PR, et al. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe. ChemMedChem. 2014 Aug;9(8):1677-82.
CoA	CoA of ML381 Fumarate

Smiles:	OC(=O)\C=C\C(O)=O.C[C@H](N(C)C(=O)C1=NOC(COC2=CC=CC(=C2)C(C)=O)=C1)C1=NC=CC=C1


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