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Product Information:

ML375

ML375 is a potent, selective and CNS penetrant M5 negative allosteric modulator (NAM).

Cat. No.: EX-A5881    Purity: >98%
Chemical
Chemical structure of ML375


For research only, Do not use for Human!

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CAS No.1488362-55-5
Purity>98%
FormulaC23H15ClF2N2O2
Mol Weight424.827
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO 40 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C 3 years, 4°C 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Patrick R Gentry, et al. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). J Med Chem. 2013 Nov 27;56(22):9351-5.

[2]. Barak W Gunter, et al. Selective inhibition of M 5 muscarinic acetylcholine receptors attenuates cocaine self-administration in rats. Addict Biol. 2018 Sep;23(5):1106-1116.

CoACoA of ML375

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