ML-209

(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells[1].


Cat. No.: EX-A14808	Purity: >98%

	Chemical structure of ML-209

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	698	In-stock
500mg	960	In-stock
1g	1720	In-stock
2g	2560	In-stock

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CAS No.	1334526-14-5
Purity	>98%
Formula	C25H31NO6
Mol Weight	441.5167
Color	Off-white to light yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jun R Huh, et al. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. ACS Med Chem Lett. 2013 Jan 10;4(1):79-84.
CoA	CoA of ML-209

Smiles:	C[C@@H]1C[C@@H](CN(C1)C(=O)CC(C2=CC3=C(C=C2)OCO3)C4=C(C=C(C=C4OC)OC)O)C


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