MKP10241

MKP10241 is an orally active GPR119 agonist. MKP10241 elevates cAMP levels in the GPR119 expressing cell line (EC50: 3.7 nM). MKP10241 reduces blood glucose levels and HbA1c in acute models and a chronic diabetic mouse model. MKP10241 also demonstrates excellent preclinical efficacy in acute as well as chronic rodent models of obesity, and MASH[1].


Cat. No.: EX-A16645	Purity: >98%

	Chemical structure of MKP10241

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
25mg	1350	In-stock
100mg	3300	In-stock

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Synonyms	MKP10241
CAS No.	2137977-29-6
Purity	>98%
Formula	C24H27FN6O3S2
Mol Weight	530.638
Color	White to off-white
State	solid
Solubility	DMSO : 25 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, sealed, 3 years; 4℃, sealed, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Rai SK, et al. Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders. J Med Chem. 2025 Oct 7.
CoA	CoA of MKP10241

Smiles:	C[C@@H](C1CCN(CC1)C2=NC=C(C=N2)CC)OC(S3)=NN4C3=NC(C5=CC=C(C=C5F)S(C)(=O)=O)=C4


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