MK-886

MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis.


Cat. No.: EX-A127	Purity: >98%

	Chemical structure of MK-886

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	400	In-stock
100mg	620	In-stock
250mg	1240	In-stock
500mg	1630	In-stock
1g	2600	In-stock
2g	4180	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	118414-82-7
Purity	>98%
Formula	C27H34ClNO2S
Mol Weight	472.082
Color	white to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15. [2]. Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64.
CoA	CoA of MK-886

Smiles:	CC(C)C1=CC2=C(C=C1)N(CC1=CC=C(Cl)C=C1)C(CC(C)(C)C(O)=O)=C2SC(C)(C)C


		Search