MK-0752

MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 reduces newly generated CNS Aβ in vivo.


Cat. No.: EX-A2100	Purity: >98%

	Chemical structure of MK-0752

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	1100	In-stock
1g	2000	In-stock
5g	get quote	Inquire

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CAS No.	471905-41-6
Purity	>98%
Formula	C21H21ClF2O4S
Mol Weight	442.904
Color	white to off-white
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cook JJ, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010;30(19):6743-6750. [2]. Krop I, et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012;30(19):2307-2313.
CoA	CoA of MK-0752

Smiles:	OC(=O)CC[C@H]1CC[C@@](CC1)(C1=CC(F)=CC=C1F)S(=O)(=O)C1=CC=C(Cl)C=C1


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