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Product Information:

MI-538

MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM.

Cat. No.: EX-A16904    Purity: >98%
Chemical
Chemical structure of MI-538


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg1200in-stock
500mg1800in-stock
1g2500in-stock


CAS No.1857417-10-7
Purity>98%
FormulaC27H25F3N8OS
Mol Weight566.601
ColorWhite to off-white
StateSolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 year;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Borkin D, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016 Feb 11;59(3):892-913.

CoACoA of MI-538
Smiles:FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=C(O)C=C(N(CC5=CNN=C5)C(C#N)=C6)C6=C4)CC3

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