MI-3454

MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis .


Cat. No.: EX-A10250	Purity: >98%

	Chemical structure of MI-3454

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	get quote	Inquire
500mg	get quote	Inquire
1g	get quote	Inquire
2g	get quote	Inquire
5g	get quote	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2134169-43-8
Purity	>98%
Formula	C32H35F3N8OS
Mol Weight	636.734
Color	Light brown to brown
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, stored under nitrogen; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Szymon Klossowski, et al. Menin Inhibitor MI-3454 Induces Remission in MLL1-rearranged and NPM1-mutated Models of Leukemia. J Clin Invest. 2020 Feb 3;130(2):981-997.
CoA	CoA of MI-3454

Smiles:	O=CNC1(C2)CC2(CN3C(C#N)=CC4=C3C=CC(CN5CCC(NC6=C(C=C(CC(F)(F)F)S7)C7=NC(NC)=N6)CC5)=C4C)C1


		Search