Mevrometostat

PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition.


Cat. No.: EX-A11760	Purity: >98%

	Chemical structure of Mevrometostat

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	450	in_stock
50mg	742	in_stock
100mg	1169	in_stock
250mg	1839	in_stock
500mg	2538	in_stock
1g	3552	in_stock

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Synonyms	PF-06821497
CAS No.	1844849-10-0
Purity	>98%
Formula	C22H24Cl2N2O5
Mol Weight	467.342
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kung PP, et al. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2018 Feb 8;61(3):650-665.
CoA	CoA of Mevrometostat

Smiles:	CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)[C@@H](C4COC4)OC)Cl)OC


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