Methotrexate alpha-tert-Butyl Ester

Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent.


Cat. No.: EX-A7576	Purity: >98%

	Chemical structure of Methotrexate alpha-tert-Butyl Ester

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	585	In-stock
50mg	885	In-stock
100mg	1485	In-stock
200mg	2285	In-stock
500mg	qet quote	In-stock
1g	qet quote	In-stock

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Synonyms	Methotrexate α-tert-Butyl Ester
CAS No.	79640-70-3
Purity	>98%
Formula	C24H30N8O5
Mol Weight	510.5456
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kaminskas LM, et al. Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers. Mol Pharm. 2011;8(2):338-349. [2]. Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73. [3]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [4]. Ehab Tousson, et al. The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine.
CoA	CoA of Methotrexate alpha-tert-Butyl Ester


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