Metallo-β-lactamase-IN-16

Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively.


Cat. No.: EX-A12785	Purity: >98%

	Chemical structure of Metallo-β-lactamase-IN-16

For research only, Do not use for Human!

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Synonyms	Metallo-β-lactamase-IN-16
CAS No.	2058069-25-1
Purity	>98%
Formula	C16H16N8O4S3
Mol Weight	480.544
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Frank Bennett, et al. Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues. Bioorg Med Chem Lett. 2024 Oct 11:114:129989.
CoA	CoA of Metallo-β-lactamase-IN-16

Smiles:	NCCS(=O)(C1=CC=C(C(C2=NNN=N2)=C1S(N)(=O)=O)C3=CC=CC4=C3N=C(S4)N)=O


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