Mertansine

Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).


Cat. No.: EX-A701	Purity: >99%

	Chemical structure of Mertansine

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	800	In-stock
500mg	1250	In-stock
1g	1950	In-stock
5g	get quote	In-stock
10g	get quote	In-stock
25g	get quote	In-stock

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Synonyms	Maytansinoid DM1
Synonyms 2	DM1
CAS No.	139504-50-0
Purity	>99%
Formula	C35H48ClN3O10S
Mol Weight	738.288
Color	white to light yellow
State	solid powder
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃ 2 years;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. [2]. Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307(2):113-8. [3]. Zhong P, et al. cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma. Nanotechnology. 2017 Jul 21;28(29):295103.
CoA	CoA of Mertansine

Smiles:	CO[C@@H]1\C=C/C=C(C)/CC2=CC(N(C)C(=O)C[C@@H](OC(=O)[C@H](C)N(C)C(=O)CCS)[C@]3(C)OC3[C@H](C)[C@@H]3C[C@@]1(O)NC(=O)O3)=C(Cl)C(OC)=C2


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